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Trudy G. Oliver, PhD (Damon Runyon-Rachleff Innovator ’13-’15), and colleagues at the Huntsman Cancer Institute at the University of Utah, Salt Lake City, reported the generation of a new mouse model for studying small cell lung cancer (SCLC). They demonstrated that Myc oncogene expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors that are initially sensitive to chemotherapy followed by relapse.
Feng Zhang, PhD (Damon Runyon-Rachleff Innovator ‘12-‘14) of the Broad Institute, Cambridge, and colleagues, reported the discovery of new types of RNA-targeting CRISPR systems, which utilize a novel Cas enzyme called Cas13b. Cas13b is capable of targeting and degrading RNA (rather than DNA, which is targeted by previous CRISPR systems), which will enable researchers to specifically manipulate RNA in a high-throughput manner and manipulate gene function more broadly.
N. Lynn Henry, MD, PhD (Damon Runyon Clinical Investigator ’10-’15) of Huntsman Cancer Institute at the University of Utah, Salt Lake City, presented a study demonstrating that a drug typically used to treat depression and anxiety (duloxetine/Cymbalta) can provide significant reductions in joint pain for women with early stage breast cancer. Many postmenopausal women are treated with aromatase inhibitors (AIs) that stop the production of estrogen and essentially starve hormone receptor-positive breast cancer cells.
Elaine V. Fuchs, PhD (Damon Runyon Board Member, Damon Runyon Fellow ‘77-‘79) of The Rockefeller University, New York, was announced the recipient of the 2016 Vanderbilt Prize in Biomedical Science. She is the 11th recipient of the Prize, which honors women scientists with a "stellar record" of research accomplishments who have made significant contributions to mentoring other women in science. Her innovative use of reverse genetics has helped redefine the study of skin diseases and cancer stem cells.
Ash Alizadeh (Damon Runyon Clinical Investigator ’14-’17) and colleagues at Stanford University School of Medicine reported that circulating tumor DNA (ctDNA) profiling by non-invasive liquid biopsy reveals distinct patterns of clonal evolution and allows accurate classification of tumor subtypes in lymphoma patients. This enables insights into the biology of how an indolent disease transitions into an aggressive and often fatal disease.
Maura L. Gillison, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05) of the Ohio State University Comprehensive Cancer Center, Columbus, was elected a member of the National Academy of Medicine. This is one of the country’s highest and most prestigious honors in the fields of health and medicine. She is recognized for having made fundamental contributions to demonstrating the link between the human papillomavirus virus (HPV) and head and neck cancers.
The NIH announced the 2016 recipients of awards within its High-Risk, High-Reward Research program. These awards are designed to support scientists proposing highly innovative approaches to major contemporary challenges in biomedical research. Of 88 total awards this year, six were granted to Damon Runyon Scientists.
2016 Pioneer Award
Christine Mayr, MD, PhD (Damon Runyon Innovator '13-'15), Memorial Sloan Kettering Cancer Center, New York
2016 NIH New Innovator Award
Dianne K. Newman, PhD (Damon Runyon Fellow ’88-‘89) of California Institute of Technology, Pasadena, was named one of 23 MacArthur Fellows for 2016. She is recognized for her innovative research investigating the role that bacteria have played in shaping the Earth and continue to play in modern biomedical contexts. The MacArthur Fellows Program awards five-year, unrestricted fellowships to individuals across all ages and fields who show exceptional merit and promise of continued creative work.
Congratulations to the six researchers named recipients of The Lasker Awards, among the most respected prizes in medicine. William G. Kaelin, Jr., MD (Damon Runyon Board Member, Chair of the Physician-Scientist Training Award Committee) of Dana-Farber Cancer Institute, Boston, received the Albert Lasker Basic Medical Research Award for his work to understand the pathway cells use to sense and adapt to changes in oxygen levels which led to the development of potential drugs for heart attack, stroke, and kidney cancer. Bruce M.
Arvin C. Dar, PhD (Damon Runyon-Rachleff Innovator '14-'16) at the Icahn School of Medicine at Mount Sinai, reported that a “scaffolding protein” called the kinase suppressor of Ras (KSR) could be targeted as a way to disrupt signaling from mutant Ras protein. About 25 percent of human cancers have mutations in the Ras protein that disrupt growth signals and cause tumor development. The researchers tested over 170 compounds and discovered that one could effectively slow cancer growth.
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