Damon Runyon Researchers

Meet Our Scientists
Zhuobin Liang, PhD

Dr. Liang [William Raveis Charitable Fund Fellow] is investigating the novel involvement of the Fanconi anemia DNA repair pathway in coordinating DNA replication and RNA transcription to maintain genome stability. Fanconi anemia (FA) is a multigenic disorder marked by progressive bone marrow failure and a strong cancer predisposition. He is employing a combination of biochemical and in vivo approaches to study the mechanism by which FA proteins attenuate aberrant DNA and RNA lesions to prevent cancers. This research promises to shed light on critical processes of genomic surveillance as well as of oncogenesis and hematopoiesis.

Project title: "Mechanistic dissection of the Fanconi anemia pathway in coordinating R-loop processing and DNA repair"
Institution: Yale University School of Medicine
Named Award: William Raveis Charitable Fund Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Patrick Sung, DPhil, and Gary Kupfer, MD
Cancer Type: Blood
Research Area: Cancer Genetics