Each cell contains organelles called mitochondria, which are the powerhouses of cells, producing energy in the form of ATP. Mitochondria contain their own separate DNA, which codes for key energy-producing enzymes. Maintaining the integrity of the mitochondrial genome is necessary for optimal cellular function and for protection against diseases. Alterations in mitochondrial DNA are associated with and can promote metastasis of many tumors, such as lung, breast and prostate. Such aberrations range from single base substitutions to large-scale deletions that remove segments of the mitochondrial genome. The mechanism by which these aberrations influence disease progression remains unclear.
Dr. Sfeir aims to uncover the underlying basis for accumulation of these highly dangerous deletions in mitochondrial DNA and the mechanism by which they shape tumor behavior. This work will help identify novel strategies to preserve mitochondrial function and thwart tumor progression.
