Damon Runyon Researchers

Meet Our Scientists
Jaehyuk Choi, MD, PhD

Cutaneous T cell lymphoma (CTCL) is an incurable cancer of the immune T cells in the skin. In advanced disease, the cells escape into the blood, the lymph nodes, and at times the visceral organs. Patients with advanced disease eventually succumb to a combination of tumor burden and disease-related immunosuppression. Dr. Choi [Doris Duke-Damon Runyon Clinical Investigator] has recently used next generation sequencing to identify gene mutations that he hypothesizes are important for CTCL pathogenesis. He will molecularly dissect how these gene mutations alter signaling pathways in CTCL, using human models and patient samples. His ultimate goal is to identify novel therapeutic strategies that selectively target CTCL cancer cells, hastening the development of a cure for this intractable disease.

Project title: "Identification of genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma"
Institution: Northwestern University
Named Award: Doris Duke-Damon Runyon Clinical Investigator
Award Program: Clinical Investigator
Sponsor(s) / Mentor(s): Stephen D. Miller, PhD, and John D. Crispino, PhD
Cancer Type: Blood
Research Area: Cancer Genetics