Damon Runyon Researchers

Meet Our Scientists
Lindsay M. LaFave, PhD

Dr. LaFave is studying how mutations in the SWI/SNF chromatin remodeling complex affect the initiation and progression of non-small cell lung cancer (NSCLC). Mutations in several SWI/SNF components have been identified in a variety of solid tumors; however, it remains unclear how their disruption contributes to tumor progression. She aims to develop novel NSCLC cell line and murine models to study the impact of SWI/SNF alterations. She will map the chromatin landscape in these models in order to characterize epigenetic changes that contribute to altered gene expression. These studies will lead to a greater understanding of SWI/SNF biology, potentially identifying novel therapeutic approaches for NSCLC patients.    

Project title: "Investigating epigenetic mechanisms of transformation in SWI/SNF-mutant non-small cell lung cancer"
Institution: Massachusetts Institute of Technology
Award Program: Fellow
Sponsor(s) / Mentor(s): Tyler Jacks, PhD
Cancer Type: Lung
Research Area: Cancer Genetics