Damon Runyon Researchers

Meet Our Scientists
Marcela V. Maus, MD, PhD

Dr. Maus has developed a way of engineering the body’s own immune T cells, so that they are re-directed to fight deadly brain tumors like glioblastoma. However, in studies of patients with brain tumors, she has found that the tumor cells try to escape the engineered T cells. She will use the Innovation Award to redesign the T cells so that they block two forms of escape used by the tumors. By preventing tumor escape from immune cells, she expects that the engineered T cells will be more powerful and may become a new form of potentially curative treatment for brain tumors. Furthermore, if this system works for brain tumors, it has potential to be applied as a therapy for other forms of cancer. 

Project title: "Next-generation CAR T cells for EGFRvIII-positive glioblastoma"
Institution: Massachusetts General Hospital
Award Program: Innovator
Cancer Type: Brain
Research Area: Immunotherapy