Damon Runyon Researchers

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Evan C. Lien, PhD

Dr. Lien is studying how diet and nutrition impact cancer cell metabolism and tumor progression. The way cancer cells utilize nutrients to support their growth and proliferation is determined not only by cancer-promoting genetic alterations, but also by the tumor’s interactions with its local environment. Diet-mediated changes in whole-body metabolism and nutrient availability are an important part of a tumor’s metabolic environment, and a better understanding of how diet modulates nutrient availability and utilization by cancer cells is needed. Moreover, the question of whether certain diets may improve prognosis is of great importance to cancer patients. He aims to provide insight into which cancer types respond to various diets, how diet impacts cancer cell metabolism to mediate these responses, and whether dietary interventions may open new therapeutic opportunities in combination with current cancer treatments. 

Project title: "Impact of diet on tumor metabolism and progression"
Institution: Koch Institute For Integrative Cancer Research at MIT
Award Program: Fellow
Sponsor(s) / Mentor(s): Matthew G. Vander Heiden, MD, PhD
Cancer Type: All Cancers
Research Area: Biochemistry