Damon Runyon Researchers

Meet Our Scientists
Benjamin R. Sabari, PhD

Dr. Sabari studies how the three-dimensional architecture of the genome plays a critical role in gene control and is altered in cancer through non-coding mutations. While many well-defined protein-coding mutations have been identified in T cell acute lymphoblastic leukemia (T-ALL), ongoing whole-genome sequencing efforts of patient T-ALL samples are revealing an unexpected level of non-coding mutations within regulatory elements critical for genome architecture. Dr. Sabari is studying how these patient mutations alter the architecture of the genome, lead to alterations in gene control and subsequent development of T-ALL. He will perform comparative analyses of three-dimensional interaction networks in normal, transformed, and genetically engineered cell populations. These studies promise to reveal novel mechanisms of T-ALL initiation and maintenance. 

Project title: "Investigating the role of aberrant genome structuring in T-ALL"
Institution: Whitehead Institute for Biomedical Research
Award Program: Fellow
Sponsor(s) / Mentor(s): Richard A. Young, PhD
Cancer Type: Other Cancer
Research Area: Epigenetics