Damon Runyon Researchers

Meet Our Scientists
Jing Lin Xie, PhD

Dr. Xie focuses on uncovering mutation-independent mechanisms of drug resistance in cancer. The prevalence of drug resistance in tumors – and collateral damage to healthy tissues – have been major roadblocks to improving the efficacy of chemotherapy. While current research has been focused on identifying mutations that confer cancer drug resistance, an emerging paradigm is that mutation-independent changes in the chromatin or proteins could be a hidden force that promotes the development of drug resistance. Her goal is to identify and characterize the heritable “molecular memories” that can confer a fitness advantage during future exposure to chemotherapeutics and other stresses.

 

Project title: "Remembering the past: epigenetic mechanisms of cancer drug resistance"
Institution: Stanford University
Named Award: The Mark Foundation for Cancer Research Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Daniel F. Jarosz, PhD
Cancer Type: All Cancers
Research Area: Epigenetics