Damon Runyon Researchers

Meet Our Scientists
Xiaoyu Zhang, PhD

Dr. Zhang is developing small molecules that promote targeted protein degradation in human cancers. Although targeted cancer therapies have been successful in recent years, many oncogenic proteins are still considered “undruggable” because the conventional drug design strategy often fails to interfere with these proteins. One potential way to address “undruggable” oncogenic proteins may be to create a new type of bifunctional small molecule that delivers these proteins to the cellular degradation system, therefore promoting their destruction.

Project title: "Discovery of chemical probes that support targeted protein degradation in human cancer"
Institution: The Scripps Research Institute
Award Program: Fellow
Sponsor(s) / Mentor(s): Benjamin F. Cravatt, PhD
Cancer Type: All Cancers
Research Area: Chemical Biology