Damon Runyon Researchers

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Robert S. Banh, PhD

In response to nutrient changes in the environment, pancreatic cancer cells can adjust the rate of mRNA translation to selectively regulate the rate of protein production. However, the specific codons—the trinucleotide sequences that correspond to specific amino acids—and regulatory mechanisms used are not known. Dr. Banh’s research aims to decipher the laws governing how codons regulate mRNA translation in response to the nutrient environment in pancreatic cancers. As cancer cells have many codon-altering mutations and are constantly adapting to changes in the nutrient environment, these studies will offer insight into tumor evolution and may uncover novel therapeutic strategies for pancreatic and other cancer patients.


Project title: “Codon- and nutrient-specific regulation of mRNA translation in pancreatic cancer”
Institution: New York University Grossman School of Medicine
Award Program: Dale Frey Scientist
Cancer Type: Pancreatic
Research Area: Biochemistry