Damon Runyon Researchers

Meet Our Scientists
Brian C. Capell, MD, PhD

Squamous cell carcinoma (SCC) can occur on a number of epithelial surface tissues ranging from the skin and lung to the esophagus and oropharynx, and collectively, are the most common form of cancer in the world. Recent sequencing studies have found that mutations in epigenetic regulators that control gene expression frequently occur in all forms of SCC. Dr. Capell aims to harness the great accessibility of human skin to understand how altered epigenetics promotes cutaneous SCC. Given that epigenetic changes are inherently reversible and numerous epigenetic drugs are currently in development, he hopes that by understanding these mechanisms he will identify better therapies for these incredibly common and potentially deadly cancers.

Project title: "Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis"
Institution: University of Pennsylvania, Philadelphia
Award Program: Clinical Investigator
Sponsor(s) / Mentor(s): Shelley L. Berger, PhD
Cancer Type: Other Cancer, Skin
Research Area: Epigenetics