Damon Runyon Researchers

Meet Our Scientists
Jingyi Wu, PhD

Dr. Wu is studying the epigenetic profile of glioma brain tumors at single cell resolution. Epigenetic alterations, which change gene expression without any changes to the underlying DNA sequence, can affect cancer driver genes in many tumor types, including gliomas. Unlike genetic mutations, epigenetic alterations are often reversible and are promising drug targets. Dr. Wu aims to determine whether there are various subpopulations of cells with distinct epigenetic features within a tumor, and whether the epigenetic differences endow these subpopulations with distinct properties, such as propensity for growth or drug resistance. These studies will lay the groundwork for precision treatment strategies targeting the fast-growing and drug-resistant cells within gliomas, and potentially other tumor types.

Project title: "Epigenetic clonal evolution in gliomas"
Institution: Massachusetts General Hospital
Award Program: Fellow
Sponsor(s) / Mentor(s): Bradley Bernstein, MD, PhD
Cancer Type: Brain
Research Area: Chromatin Biology