Damon Runyon Researchers

Meet Our Scientists
Ge Zheng, PhD

Dr. Zheng is taking an interdisciplinary approach to understand how transcription factors that regulate the transcription of DNA to RNA malfunction in human cancers. The B cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger transcription factor, which plays a critical role in silencing fetal globin expression in the fetal-to-adult switch in red blood cells and is implicated in cancer. Dr. Zheng aims to develop novel approaches to interfere with BCL11A function, which will provide a general strategy to manipulate transcription factors as molecular targets for therapeutic benefit.

Project title: "Novel approaches to targeting zinc-finger domain of the transcription repressor BCL11A"
Institution: Boston Children's Hospital
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Stuart H. Orkin, MD
Cancer Type: All Cancers
Research Area: Cell Biology