Dr. Zheng [HHMI Fellow] is taking an interdisciplinary approach to understand how transcription factors that regulate the transcription of DNA to RNA malfunction in human cancers. The B cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger transcription factor, which plays a critical role in silencing fetal globin expression in the fetal-to-adult switch in red blood cells and is implicated in cancer. Dr. Zheng aims to develop novel approaches to interfere with BCL11A function, which will provide a general strategy to manipulate transcription factors as molecular targets for therapeutic benefit.
Damon Runyon Researchers
Meet Our Scientists
Ge Zheng, PhD
Project title: "Novel approaches to targeting zinc-finger domain of the transcription repressor BCL11A"
Institution: Boston Children's Hospital
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Stuart H. Orkin, MD
Cancer Type: All Cancers
Research Area: Cell Biology
