Damon Runyon Researchers

Meet Our Scientists
Sigrid Nachtergaele, PhD

Dr. Nachtergaele is investigating the roles of RNA methylation, a process that chemically tags mRNA to alter gene expression and protein production. She has discovered a novel enzyme (m1A) that modifies RNA in this way and aims to uncover how malfunctions in this process can lead to cancer. Her investigations will expand the understanding of how mRNA modifications are regulated and result in altered cell signaling and growth in normal and cancer cells.  Building on this knowledge, her goal is to identify novel therapeutic targets for cancer.

Project title: "Identifying novel mechanisms of gene expression regulation through mRNA modifications"
Institution: Yale University
Award Program: Dale Frey Scientist
Cancer Type: All Cancers
Research Area: Chemical Biology