Damon Runyon Researchers

Cancers originating from different tissue types harbor distinct genetic mutations. Using molecular and systematic approaches in genetics, Dr. Chiba will dissect the mechanisms of how distinct combinations of oncogenic mutations drive tumors from different tissue origins. Due to the differing genetic background of these tumors, the efficacy of therapies that target the same oncogenic mutations varies between tumor types. Thus, understanding multiple different mutations in a tissue-specific context is critical for effective precision therapies.