Damon Runyon Researchers

Meet Our Scientists
Janice M. Reimer, PhD

Dr. Reimer studies the molecular mechanisms that regulate the SWI/SNF family of chromatin remodelers, which is mutated in over 20% of cancers. Condensed DNA is stored within the nucleus as chromatin, which cannot be accessed for transcription to proteins. Chromatin remodelers are complex protein machines that alter DNA accessibility. Gain-of-function mutations lead to functional complexes with abnormal activities and are potential therapeutic targets. Dr. Reimer will use cryo-electron microscopy to understand how oncogenic mutations may disrupt the normal regulation and behavior of SWI/SNF remodelers.

Project title: "Regulation of nucleosome remodelers"
Institution: University of California, San Diego
Named Award: Merck Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Andres Leschziner, PhD
Cancer Type: All Cancers
Research Area: Structural Biology