Damon Runyon Researchers

Meet Our Scientists
Steven W.M. Crossley, PhD

Dr. Crossley is developing reaction-based chemistry to address the problem of “undruggable” targets in cancer therapy. These proteins lack grooves or “pockets” on the surface that can potentially bind small molecule drugs. A small molecule that can react with an amino acid in the target protein, forming a covalent bond, may circumvent the problem of poor binding pockets. Dr. Crossley aims to find drugs that will target the most problematic cancer-causing proteins, expanding the potential to treat cancers that currently have few therapeutic options.

Project title: "Mapping targets for cancer therapeutics via methionine-selective warheads"
Institution: University of California, Berkeley
Named Award: AGBT-Elaine R. Mardis Fellowship in Cancer Genomics
Award Program: Fellow
Sponsor(s) / Mentor(s): Christopher J. Chang, PhD, and Daniel K. Nomura, PhD
Cancer Type: All Cancers
Research Area: Drug Discovery