Damon Runyon Researchers

Meet Our Scientists
Shou-Wen Wang, PhD

Many blood cancers, including leukemia and multiple myeloma, arise when early blood-forming cells do not develop properly. These aberrant cell fate choices cause abnormal blood cells to grow and divide uncontrollably. By combining lineage tracing, single-cell RNA sequencing (scSeq), and computational analysis, Dr. Wang aims to first develop a theoretical foundation and then build computational pipelines that reliably infer the order of events in cellular differentiation from these datasets. The results of this research may empower other biologists to systematically map out cell fate choice in their preferred systems. Applying the tools developed here to study perturbed blood formation (hematopoiesis) may also accelerate progress in understanding blood cancers.

Project title: "Inferring cell fate choice from clonal and transcriptomic data, with application to hematopoiesis"
Institution: Harvard Medical School
Award Program: Quantitative Biology Fellow
Sponsor(s) / Mentor(s): Allon M. Klein, PhD, and Fernando Camargo, PhD
Cancer Type: Blood