Damon Runyon Researchers

Meet Our Scientists
Collin Tokheim, PhD

Unlike traditional drugs that bind and block the activity of key proteins in cancer cells, a new generation of drugs can eliminate proteins by hijacking the protein degradation machinery within cells. Dr. Tokheim is developing computational models that can identify degradable proteins that are linked to the development of human cancers. By leveraging big data from thousands of tumor profiles and a novel statistical and deep learning model, he will conduct an unbiased search for candidate proteins that can be verified experimentally. This research may lead to the development of drugs targeting protein degradation as a potent and selective way to treat a variety of human cancers.

Project title: "Computationally identifying oncogenic substrates of the ubiquitin-proteasome system in human cancers"
Institution: Dana-Farber Cancer Institute
Award Program: Quantitative Biology Fellow
Sponsor(s) / Mentor(s): X. Shirley Liu, PhD, and Eric S. Fischer, PhD
Cancer Type: All Cancers