Damon Runyon Researchers

Meet Our Scientists
Marco A. Catipovic, PhD

Dr. Catipovic focuses on the mechanisms governing the resolution of errors that arise during RNA translation in mammals. Ribosomes translating the same message can collide if they are damaged or encounter blockages. If not resolved quickly, these collisions activate cellular signaling pathways implicated in a number of cancers. Dr. Catipovic uses reconstituted translation systems, consisting of purified translation factors in vitro (or “in a test tube”), as a tool to study quality control pathways for ribosomes engaged in collisions. These pathways identify and recycle any damaged ribosomal components before the cell can mount more severe, oncogenic responses.

Project title: "The role of ribosome biogenesis in recycling damaged ribosomes"
Institution: The Johns Hopkins University School of Medicine
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Rachel Green, PhD
Cancer Type: All Cancers
Research Area: Biochemistry