Damon Runyon Researchers

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Madi Y. Cissé, PhD

Dr. Cissé aims to define the functional importance of nutrient sensing within the tumor microenvironment. How cells sense and adapt to the availability of nutrients in their environment is incompletely understood, but one key pathway is the signaling system anchored by the mTORC1 kinase. The mTORC1 kinase regulates cell growth and metabolism in response to nutrients such as amino acids and glucose. Aberrant mTORC1 signaling is implicated in several cancers, including melanoma, known to be heavily influenced by factors in the microenvironment such as nutrient availability. Dr. Cissé aims to understand how tumor metabolism senses and responds to varying nutrient levels, which will be essential for developing novel therapeutic targets.

Project title: "Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
Institution: Harvard T.H. Chan School of Public Health
Named Award: Merck Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Brendan D. Manning, PhD
Cancer Type: Skin, All Cancers
Research Area: Metabolism