Damon Runyon Researchers

Meet Our Scientists
Edie I. Crosse, PhD

Dr. Crosse focuses on myelodysplastic syndromes (MDS), blood cancers that occur predominantly in the elderly. These cancers are initiated in the bone marrow when blood stem cells acquire a genetic mutation that causes them to divide and multiply uncontrollably. Through proliferation and acquisition of further mutations, the disease can evolve into acute myeloid leukemia, for which prognosis and survival rate are typically poor. Dr. Crosse aims to identify the specific blood stem cells that are most impacted by the mutation in the early stages of MDS and determine how they contribute to disease progression. The goal is to design therapies that inhibit these mechanisms and halt MDS cancer progression.

Project title: "Determining the role of stem cell heterogeneity in clonal evolution of hematologic malignancy"
Institution: Fred Hutchinson Cancer Research Center
Named Award: Illini 4000 Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Lev Silberstein, MD, PhD, and Irwin D. Bernstein, MD
Cancer Type: Blood, All Cancers
Research Area: Cancer Genetics