Damon Runyon Researchers

Meet Our Scientists
Bo Gu, PhD

Dr. Gu [Fraternal Order of Eagles Fellow] is deciphering the combinatorial code of mammalian transcription regulation. The precise and robust regulation of gene expression is typically achieved through a combination of multiple transcription factors. However, we lack understanding of how a mammalian transcription system perceives, processes, and presents combinations of transcription factors. Dr. Gu will combine quantitative modeling and synthetic approaches to analyze the complex interactions among natural transcription regulatory proteins and apply the principles learned to engineer a programmable transcriptional platform with tunable logic. This work promises to deepen our understanding of mammalian transcription regulation and unlock new capabilities for emerging cell-based therapeutics.

Project title: "Understanding and engineering combinatorial gene regulation in mammalian cells"
Institution: California Institute of Technology
Named Award: Fraternal Order of Eagles Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Michael B. Elowitz, PhD
Cancer Type: All Cancers
Research Area: Systems Biology