Damon Runyon Researchers

Meet Our Scientists
Edward M. C. Courvan, PhD

Macrophages are specialized immune cells responsible for “eating” harmful cells, presenting antigens to T cells, and initiating inflammation by releasing signaling molecules called cytokines. Macrophages could potentially be activated to attack tumor cells, but for reasons that are currently unclear, they instead signal for the tumor to grow faster and become more invasive. Dr. Courvan [HHMI Fellow] is investigating how macrophages respond to the low-oxygen environment inside tumors, and specifically how they regulate gene expression through post-transcriptional mechanisms in low-oxygen conditions. With this research, he hopes to uncover new ways to leverage the body's immune system against cancerous cells. Dr. Courvan received his PhD from Yale University and his BS from the University of Connecticut.

Project title: "Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
Institution: University of Colorado Boulder
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Roy R. Parker, PhD
Cancer Type: All Cancers
Research Area: Biochemistry