Damon Runyon Researchers

Meet Our Scientists
James Osei-Owusu, PhD

The relaxin-2 receptor (RXFP1), which binds a hormone aptly known as relaxin, plays a key role in reproductive and cardiovascular physiology by increasing blood flow and facilitating childbirth. Abnormal signaling of the receptor leads to a variety of cancers, particularly tumors of reproductive tissues. James aims to establish a comprehensive understanding of RXFP1 molecular signaling and how it can be inhibited for cancer treatment. This study will facilitate the discovery of candidate therapeutic agents as well as aid the rational design of drugs for reproductive cancer treatment. Dr. Osei-Owusu received his PhD from Johns Hopkins University, Baltimore and his MSc and BSc from the University of Ghana, Legon.


Project title: "Structure and inhibition of the relaxin receptor RXFP1"
Institution: Harvard Medical School
Award Program: Fellow
Sponsor(s) / Mentor(s): Andrew C. Kruse, PhD
Cancer Type: Other Cancer, Breast, Prostate
Research Area: Structural Biology