Damon Runyon Researchers

Meet Our Scientists
Nicole M. Hoitsma, PhD

Human cells have complex mechanisms to repair DNA damage, such as that caused by exposure to sunlight or chemical substances. If DNA is not properly repaired, however, it can lead to cancer. In fact, faulty DNA repair has been associated with the initiation and progression of all types of cancer and is often targeted in cancer treatment to stop uncontrolled cell growth. A better understanding of how cells naturally defend against DNA damage will allow for the development of better drugs to treat cancer. Dr. Hoitsma [HHMI Fellow] aims to investigate specialized proteins, known as chromatin remodelers, that make damaged DNA accessible for repair. This research will provide insight for the development of novel therapeutic strategies to target these critical pathways. Dr. Hoitsma received her PhD from University of Kansas Medical Center, Kansas City and her BS from South Dakota State University, Brookings.

Project title: "Chromatin remodeler SMARCAD1 in DNA repair"
Institution: University of Colorado Boulder
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Karolin Luger, PhD
Cancer Type: All Cancers
Research Area: Chromatin Biology