Damon Runyon Researchers

Meet Our Scientists
Alon Chappleboim, PhD

Dr. Chappleboim studies how cells communicate during a developmental process called somitogenesis, which drives the formation of repeated structures such as the spinal vertebrae. The signals that guide cell communication during this process can get misinterpreted by cancer cells, resulting in uncontrolled growth. These pathways are implicated in numerous cancer types but are notably associated with colorectal, ovarian, and breast cancer. Using cutting-edge techniques in human stem cells and 3D-models called organoids, along with the tools of computational biology, Dr. Chappleboim aims to deliberately perturb and examine these signaling pathways to gain a comprehensive understanding of how they function. Dr. Chappleboim received his PhD, MS, and BS from Hebrew University of Jerusalem, Jerusalem.

Project title: "Uncovering signaling mechanisms in somitogenesis through high-throughput genetic screens in robust human organoids"
Institution: Harvard University
Award Program: Fellow
Sponsor(s) / Mentor(s): Sharad Ramanathan, PhD
Cancer Type: All Cancers
Research Area: Developmental Biology