Damon Runyon Researchers

Meet Our Scientists
Joseph D. Schonhoft, PhD

Dr. Schonhoft [Merck Fellow] aims to understand how immune cells abnormally proliferate and secrete a pathogenic variety of antibody proteins that cause organ and tissue damage, most notably in the heart and kidneys, during diseases such as amyloidosis and within a subset of multiple myelomas. His research will explain why particular antibody molecules are toxic while others are completely benign. This information may be used to develop new diagnostic probes for the early detection of these molecules, which could greatly improve the effectiveness of current clinical treatments.

Project title: "Probing the relation between sequence, agrregation and proteotoxicity in cardiac amyloidoses caused by free antibody light chains"
Institution: The Scripps Research Institute
Named Award: Merck Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Jeffery W. Kelly, PhD
Cancer Type: Blood
Research Area: Biochemistry