Triple-negative breast cancer (TNBC) is one of the most aggressive and difficult-to-treat forms of breast cancer. Dr. Bruno’s research focuses on how changes in DNA packaging, known as chromatin, affect cancer progression and treatment response. Using advanced computational models, Dr. Bruno will investigate the interplay between chromatin modifications and resistance mechanisms, with the goal of identifying strategies to mitigate therapy resistance and reduce cancer recurrence. While Dr. Bruno’s primary focus is TNBC, this research provides a generalizable framework that could be applied to other cancers where chromatin modifications play a key role, leading to better, more durable treatments for a broader range of patients.
In this project, Dr. Bruno will develop a computational framework that integrates mathematical models of chromatin modification dynamics with pharmacokinetic and pharmacodynamic models to study the role of these modifications in triple-negative breast cancer (TNBC) progression. Dr. Bruno will adapt existing chromatin modification circuit models to TNBC dynamics and, using Bayesian inference methods, will parameterize them with experimental data. By integrating pharmacokinetic models for specific drugs, this framework will enable the evaluation of diverse treatment strategies.
