Damon Runyon Researchers

Meet Our Scientists
Keren I. Hilgendorf, PhD

Dr. Hilgendorf [Layton Family Fellow] is exploring the role of primary cilia in regulating cell proliferation and differentiation. The primary cilium is an antenna-like cellular protrusion that is localized on the apical surface of most vertebrate cells in diverse tissue; it functions in chemo- and mechanosensation. In many cancers, primary cilia are lost so cilia-mediated signaling pathways are deregulated. Understanding the molecular components and functions of ciliary signaling will further our understanding of mechanisms of tumorigenesis and evaluate the importance of primary cilia in cancer.

Project title: "Role of ciliary IGF-1/AKT signaling in ciliogenesis, adipogenesis, and tissue regeneration"
Institution: Stanford University School of Medicine
Named Award: Layton Family Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Peter K. Jackson, PhD
Cancer Type: All Cancers
Research Area: Signal Transduction