New Discoveries and Honors in Cancer Research

Read the latest cancer research and recognition from the members of the Damon Runyon scientific circle.
March 5, 2015
Genome-wide screen gives insight on cancer metastasis and tumor evolution

Sidi Chen, PhD (Damon Runyon-Dale F. Frey Scientist ‘15, Damon Runyon Fellow '12-'15) and Feng Zhang, PhD (Damon Runyon-Rachleff Innovator '12-'14), of the Broad Institute and MIT’s David H. Koch Institute for Integrative Cancer Research, Cambridge, used CRISPR-Cas9 gene-editing technology to systematically target every gene in the genome in an animal model. The study revealed genes involved in tumor evolution and metastasis, including some well-known tumor suppressor genes as well as novel genes not previously linked to cancer. The work was published in the journal Cell.