New Discoveries and Honors in Cancer Research

Read the latest cancer research and recognition from the members of the Damon Runyon scientific circle.
April 16, 2012
Targeting apoptosis for cancer therapy

Guo Wei, PhD (Damon Runyon Fellow ‘05-‘08), Todd R. Golub, MD (Innovation Award Committee Member, Board Member) and colleagues at Dana-Farber Cancer Institute and The Broad Institute, Cambridge, used chemical genomics to identify compounds that decrease activity of MCL1, a protein that helps keep cells alive (anti-apoptotic) and is frequently overexpressed in cancer. In addition, the researchers found that high expression of another gene, BCL-xL, confers resistance to MCL1 repression. These compounds could be developed as cancer therapeutics to treat MCL1-dependent tumors, using BCL-xL as a biomarker to predict whether a tumor will respond to therapy. This study was published in the journal Cancer Cell