Blood Cancers

Current Projects
Evan J. Worden, PhD

Dr. Worden examines how the decision to “turn on” or “turn off” genes is determined by a highly coordinated series of events that rely on the chemical modification of histone proteins. Misregulation of histone modification can cause a variety of human cancers. Dr. Worden is using structural biology and biophysical approaches to understand how the precise patterning of histone modifications - the “histone code” - is established. He plans to study the regulatory mechanisms that control histone methylation, which is important for the formation of leukemias.

Project title: "The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation"
Institution: The Johns Hopkins University School of Medicine
Award Program: Fellow
Sponsor(s) / Mentor(s): Cynthia Wolberger, PhD
Cancer Type: Blood, All Cancers
Research Area: Biophysics
Yi Yin, PhD

Dr. Yin has developed single-cell assays that will be combined with statistical modeling to understand homologous recombination (HR). Cells use the process of HR to accurately repair harmful breaks that occur on both strands of DNA. Failure to correct such DNA damage can play a role in cancer initiation and progression. Dr. Yin aims to understand this critical mechanism to help guide treatment approaches for many cancer types.

Project title: "Global analysis of DNA break repair by single-cell sequencing"
Institution: University of California, Los Angeles
Award Program: Dale Frey Scientist
Cancer Type: Blood, Breast, Skin
Research Area: Chromosome and Telomere Biology
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