Breast Cancer

Current Projects
Leeat Yankielowicz-Keren, PhD

Dr. Yankielowicz-Keren studies cellular changes in breast cancer, the second leading cause of cancer death in women in the U.S. Recently, a new multiplexed ion beam imaging (MIBI) technology has been introduced, which enables simultaneous imaging of dozens of proteins at a single cell level within a tissue section with high sensitivity. She is applying MIBI to study expression patterns of human breast cancer samples in the spatial context of the microenvironment and the interactions with the immune system. She aims to discover novel phenotypic and histologic features that predict progression from contained lesions to invasive disease.

Project title: "Studying the tumor immune microenvironment in breast cancer using a novel multiplexed imaging platform"
Institution: Stanford University
Award Program: Fellow
Sponsor(s) / Mentor(s): Michael R. Angelo, MD, PhD
Cancer Type: Breast
Research Area: Systems Biology
Yi Yin, PhD

Dr. Yin is using newly developed state-of-the-art single cell sequencing technology to examine how DNA repair mechanisms go awry and contribute to cancer initiation and progression, as well as response to chemotherapy. Cancer cells usually have characteristic loss-of-heterozygosity, copy number variation and other types of genome rearrangements. A better understanding of the molecular mechanisms, genomic and cell contexts and effects from different allele variants in DNA repair genes of each individual may help guide treatment approaches for many cancer types, including breast, skin, and blood cancers.

Project title: "Global analysis of DNA break repair by single-cell sequencing"
Institution: University of Washington
Award Program: Fellow
Sponsor(s) / Mentor(s): Jay A. Shendure, MD, PhD
Cancer Type: Blood, Breast, Skin, All Cancers
Research Area: Chromosome and Telomere Biology
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