Skin Cancer

Current Projects
Linghe Xi, PhD

Dr. Xi is studying signaling events that drive squamous cell carcinomas (SCCs), a common form of skin cancer. She focuses on WNT signaling, which is an important player in cell fate determination. It appears that WNT signaling is essential for SCC tumor formation, but exactly where and how it is required remains unknown. She is dissecting the activity of WNT signaling during the progression from normal epithelial cells to benign papillomas, and then to malignant SCC tumors. She is also investigating the critical downstream effectors of WNT signaling in this process, in order to identify improved targets for cancer therapeutics.

Project title: "WNT signaling and fate specification of normal versus tumorigenic stem cells"
Institution: The Rockefeller University
Named Award: Dale F. and Betty Ann Frey Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Elaine Fuchs, PhD
Cancer Type: Skin
Research Area: Stem Cell Biology
Yi Yin, PhD

Dr. Yin is using newly developed state-of-the-art single cell sequencing technology to examine how DNA repair mechanisms go awry and contribute to cancer initiation and progression, as well as response to chemotherapy. Cancer cells usually have characteristic loss-of-heterozygosity, copy number variation and other types of genome rearrangements. A better understanding of the molecular mechanisms, genomic and cell contexts and effects from different allele variants in DNA repair genes of each individual may help guide treatment approaches for many cancer types, including breast, skin, and blood cancers.

Project title: "Global analysis of DNA break repair by single-cell sequencing"
Institution: University of Washington
Award Program: Fellow
Sponsor(s) / Mentor(s): Jay A. Shendure, MD, PhD
Cancer Type: Blood, Breast, Skin, All Cancers
Research Area: Chromosome and Telomere Biology
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