Lung Cancer

Current Projects
Liron Bar-Peled, PhD

Dr. Bar-Peled studies how cancer cells adapt to stress environments, focusing on oxidative stress.  His research focuses on understanding how cells sense and respond to specific changes in their environment by activating singling pathways that lead to uncontrolled growth.  He recently studied a particular pathway in non-small cell lung cancer and identified a “druggable” protein that could be targeted with small molecules and disrupt this uncontrolled growth. He plans to pursue this specific target and use the same strategy for identifying druggable pathways in other cancers that currently lack effective therapies.

Project title: "Identification of cysteine liabilities in NRF2-driven cancers"
Institution: The Scripps Research Institute
Award Program: Dale Frey Scientist
Cancer Type: Lung, All Cancers
Research Area: Chemical Biology
Angela N. Brooks, PhD

Dr. Brooks is analyzing cancer genome sequence data to identify DNA mutations that affect RNA splicing, a form of gene processing and regulation. By characterizing these mutations, her work will provide further understanding of the role of splicing alterations in cancer as well as insight into the functional consequences of cancer mutations.

 

Project title: "Characterizing somatic mutations that affect mRNA splicing in cancer"
Institution: University of California, Santa Cruz
Award Program: Dale Frey Scientist
Cancer Type: Blood, Lung, All Cancers
Research Area: Genomics
Aude G. Chapuis, MD

Non-small cell lung cancer (NSCLC) is a particularly aggressive type of lung cancer, and mesothelioma is an equally aggressive cancer of the lining of the lung. Despite recent therapeutic advances, approximately 190,000 and 3,000 Americans respectively succumb to these cancers each year, emphasizing the urgent need for more effective treatments. Therapies that use cancer-recognizing immune T cells are especially promising. T cells specifically bind particular tumor-associated molecules (antigens) and kill bound cancer cells through proteins called "T cell receptors" (TCRs). Once an appropriate tumor antigen-specific TCR has been identified, genetic engineering can be used to add that TCR to a patient's T cells, thus educating them to recognize the cancer. The educated immune cells are then infused into patients, where they can seek out and destroy cancer without damaging normal tissues.

Dr Chapuis' studies will target Wilms' tumor antigen 1 (WT1), found not only on NSCLC and mesothelioma cancer cells but also on leukemia cells. She previously led studies of this approach for leukemia, which is now showing promise in the clinic for patients. Her new studies aim to develop a similar safe and effective immunotherapy for patients with deadly lung cancers, with the ultimate goal to entirely bypass the current need for toxic drug and radiation treatments.

Project title: "To specify the requirements of CD8+ and CD4+ T cells for successful adoptive transfer in solid tumors"
Institution: Fred Hutchinson Cancer Research Center
Award Program: Clinical Investigator
Sponsor(s) / Mentor(s): Philip D. Greenberg, MD
Cancer Type: Lung
Research Area: Immunotherapy
Sidi Chen, PhD

Dr. Chen aims to understand the relationship between small RNAs and cancer.  Small RNAs are important regulators of genetic networks inside the cell; perturbation of these networks can lead to malignant cell growth.  His goal is to develop anti-cancer drugs and therapies by targeting the process of small RNA production.

Project title: "Investigation of Dicer as a novel therapeutic route towards the inhibition of tumorigenesis and neoplastic growth"
Institution: Yale University
Award Program: Dale Frey Scientist
Cancer Type: Lung, Sarcoma
Research Area: Cancer Genetics
Kathrin Leppek, PhD

Dr. Leppek [Layton Family Fellow] aims to combine RNA and ribosome biology with developmental biology to investigate how cells regulate protein synthesis through a process called translation. This process requires regulatory mechanisms to fine-tune when and where genes are expressed. Defective expression of certain genes gives rise to uncontrolled growth and metastasis of cancer cells. She will identify and characterize molecular components that play a functional role in mediating translational control during embryogenesis. This will be invaluable for our understanding of how deregulation of accurate gene expression underlies human diseases such as cancer.

Project title: "Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development"
Institution: Stanford University
Named Award: Layton Family Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Maria Barna, PhD
Cancer Type: Blood, Gastric, Gynecological, Breast, Colorectal, Lung, Pancreatic
Research Area: Developmental Biology
Yin Liu, PhD

Dr. Liu [Layton Family Fellow] studies lung biology. The lung is innervated by diverse types of sensory neurons, collectively called pulmonary sensory neurons. These neurons detect a variety of physiological stimuli from the lung and inform the central nervous system about the state of the lung. Lung cancer, one of the most common cancers with a high rate of lethality, is associated with symptoms such as chronic cough, shortness of breath, and referred cranial facial pain. Her research will examine how pulmonary sensory neurons recognize and respond to lung tumors, and how this tumor sensing influences tumor biology. She aims to understand which populations of pulmonary sensory neurons mediate lung cancer-associated clinical symptoms, how these neurons alter their behaviors in response to tumor growth, and how activating pulmonary sensory pathways affects cancer progression and metastases.

Project title: "Sensing lung tumors by pulmonary sensory neurons"
Institution: Stanford University
Named Award: Layton Family Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Mark A. Krasnow, MD, PhD
Cancer Type: Lung
Research Area: Neuroscience
Sigrid Nachtergaele, PhD

Dr. Nachtergaele [HHMI Fellow] is investigating the roles of a chemical modification of mRNA called methylation. Many enzymes that add and remove RNA modifications impact developmental processes and cancer proliferation, but how they are regulated remains a mystery. She aims to identify the mechanisms by which mRNA methylation alters gene expression and eventually results in altered cell signaling and growth. Her goals are to understand these regulatory principles, to uncover how they become misregulated in disease, and to exploit these processes to identify novel cancer therapeutic targets.

Project title: "The dynamic N1-methyladenosine methylome in eukaryotic mRNA"
Institution: The University of Chicago
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Chuan He, PhD
Cancer Type: Blood, Breast, Lung
Research Area: Chemical Biology
Trudy G. Oliver, PhD

Many cancers initially respond to therapy. However, cancers often acquire resistance and stop responding to further treatment. Small cell lung cancer (SCLC) is an example of a cancer that is highly sensitive to initial treatment, but quickly acquires a vicious resistance resulting in a five-year patient survival rate of less than 4%. In order to combat drug resistance and improve the quality of life for patients with SCLC, it is important to understand the key genetic changes and cellular pathways that drive resistance.

Dr. Oliver will use the most innovative next-generation sequencing technologies to comprehensively identify critical genetic changes associated with resistance. These findings will be essential for understanding how lung cancer, and potentially other types of cancer, evades chemotherapy. In addition, this work will identify novel pathways that could be targeted to re-establish drug sensitivity and thereby provide new treatment options for patients with drug-resistant disease.  

 

Project title: "Mechanisms of drug resistance in small cell lung cancer"
Institution: University of Utah
Award Program: Innovator
Cancer Type: Lung
Research Area: Chemoresistance
Jeanine L. Van Nostrand, PhD

Dr. Van Nostrand aims to understand how signaling pathways involved in the energetic and metabolic stress responses prevent cancer. She will generate mouse models harboring specific mutations that prevent the stress response, and evaluate the effects of these mutations on lung cancer development. Furthermore, using exercise and caloric restriction, she will elicit the metabolic stress response in these animals to understand how energetic stresses prevent cancer development and progression. This work will both expand knowledge of how cells respond to energy stress and metabolic changes to suppress tumorigenesis and aid in establishing effective preventative and therapeutic strategies for cancer patients.

Project title: "Elucidating the AMPK-dependent regulation of mTOR signaling in the metabolic checkpoint of tumorigenesis"
Institution: The Salk Institute for Biological Studies
Award Program: Fellow
Sponsor(s) / Mentor(s): Reuben J. Shaw, PhD
Cancer Type: Lung
Research Area: Animal Models/Mouse Models
Victoria E.H. Wang, MD, PhD

Dr. Wang seeks to understand the mechanisms by which tumor cells become resistant to drug therapy and spread to distant organs. She is utilizing functional genomics tools to identify novel pathways modulating these processes in the hope of developing new therapies to augment treatment response in cancer patients. 

Project title: "The role of the c-Met/Hepatocyte growth factor (HGF) pathway in drug resistance and tumor metastasis"
Institution: University of California, San Francisco
Award Program: Fellow
Sponsor(s) / Mentor(s): Frank McCormick, PhD
Cancer Type: Other Cancer, Lung, All Cancers
Research Area: Chemoresistance
  • You can support our innovative researchers.