Ryan D. Baldridge, PhD

The goal of this research is to increase our understanding of the integral membrane protein quality control systems. These systems are involved in regulation of proteins in different cellular organelles. One of these systems, called endoplasmic reticulum associated degradation (ERAD), plays a central role in many cancer processes by regulating the levels of proteins involved in tumor growth and metastasis. A common feature of all types of cancer is survival during unfavorable conditions that would trigger apoptosis in normal cells.

Swathi Yadlapalli, PhD

Dr. Yadlapalli [HHMI Fellow] aims to elucidate the neural and molecular mechanisms involved in the regulation of metabolism. Living organisms from insects to humans have evolved neural mechanisms involving circadian clocks to synchronize their physiology, metabolism and behavior with the external environment. Disruption of these clocks is associated with increased incidence of cancer, diabetes, and heart disease.

Costas A. Lyssiotis, PhD

Dr. Lyssiotis focuses on how oncogenes affect cellular metabolism in pancreatic cancer. In particular, he is interested in understanding how mutations in the oncogene Kras alter cellular metabolism in pancreatic ductal adenocarcinoma to facilitate cell growth. He will determine if distinct components of Kras-mediated signaling can be targeted for therapeutic gain. Ultimately, this work aims to translate our understanding of pancreatic cancer cell metabolism into therapies for this devastating disease.