Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
California Institute of Technology
Zibo Chen, PhD
"Combinatorial signal classification with a protein-based synthetic neural network"
with Michael Elowitz, PhD
Stanford University
Jennifer L. Caswell-Jin, MD
"Breast cancer evolution and resistance in response to HER2-targeted therapy"
with Christina N. Curtis, PhD, and Allison W. Kurian, MD
Ryan A. Flynn, MD, PhD
"The interplay between cellular metabolism and RNA homeostasis in disease"
with Carolyn R. Bertozzi, PhD
Christina L. Hueschen, PhD
"Molecular basis and regulation of apicomplexan parasite motility"
with Alex Dunn, PhD
Victoria Hung, PhD
"Defining the post-translational landscape of ribosomes in control of gene regulation and cell fate"
with Maria Barna, PhD
John C. Janetzko, PhD
"A biophysical approach to studying GRK-GPCR complexes"
with Brian K. Kobilka, MD
Chuan Li, PhD
"Quantifying epistasis between tumor suppressor genes and revealing the underlying expression profiles at the single-cell level in murine lung adenocarcinoma"
with Dmitri Petrov, PhD
Fangfei Qu, PhD
"Decoding the molecular and cellular mechanisms underlying the growth of brain metastases"
with Julien Sage, PhD
Kavita Y. Sarin, MD, PhD
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
with Jean Y. Tang, MD, PhD, and Anthony E. Oro, MD, PhD
Jianjin Shi, PhD
"Biochemical and genetic dissection of axon degeneration"
with Marc Tessier-Lavigne, PhD
Shaogeng (Steven) Tang, PhD
"Toward small-molecule inhibitors against human immune checkpoint PD-1"
with Peter S. Kim, PhD
Kathryn R. Taylor, PhD
"The effect of neuronal activity on pediatric glioma invasion"
with Michelle L. Monje, MD, PhD
Peng Wu, MD, PhD
"Understanding and modulating aberrant differentiation in Hepatoblastoma"
with Roeland Nusse, PhD
Stanford University School of Medicine
Christopher P. Lapointe, PhD
"Regulatory roles of the 3' untranslated region in human translation"
with Joseph Puglisi, PhD
The Salk Institute for Biological Studies
Hokyung K. Chung, PhD
"Next generation adoptive cell therapy: SMARTER T cells for enhanced and durable anti-tumor immunity"
with Susan Kaech, PhD
University of California, Berkeley
Tess C. Branon, PhD
"Elucidating mechanisms of bidirectional host-microbiota communication"
with Gregory M. Barton, PhD
Steven W.M. Crossley, PhD
"Mapping targets for cancer therapeutics via Methionine-selective warheads"
with Christopher J. Chang, PhD, and Daniel K. Nomura, PhD
Allison Didychuk, PhD
"Viral mimics of host transcription factors in oncogenic herpesviruses"
with Britt Glaunsinger, PhD
Stephanie Gates, PhD
"Decoding the ubiquitin receptor recognition mechanism of the 26S proteasome"
with Andreas Martin, PhD
Jamie Lahvic, PhD
"Uncovering cell non-autonomous mechanisms of tumor suppression"
with Iswar Hariharan, MBBS, PhD
Andrew C. Murley, PhD
"Cell non-autonomous communication of ER stress resistance"
with Andrew G. Dillin, PhD
University of California, Los Angeles
Christina M. Termini, PhD
"Proteoglycan remodeling of the bone marrow niche regulates hematopoietic stem cell regeneration"
with John P. Chute, MD
University of California, San Francisco
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to osimertinib in EGFR-mutant lung cancer"
with Trever G. Bivona, MD, PhD
Vladislav Belyy, PhD
"Mapping the unfolded protein response signaling network with optogenetic actuators"
with Peter Walter, PhD
Julia C. Carnevale, MD
"Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects"
with Alan Ashworth, PhD
Kyle G. Daniels, PhD
"Controlling T cell signaling and fate choice using synthetic receptors"
with Wendell Lim, PhD
Trang Nguyen, PhD
"Bypassing the unresponsiveness of T cell anergy and exhaustion"
with Arthur Weiss, MD, PhD
Zulekha A. Qadeer, PhD
"Targeting TGFb pathway dependencies in Group 3 Medulloblastoma"
with William A. Weiss, MD, PhD
Sukrit Silas, PhD
"Discovery and characterization of virally-encoded proteins of unknown function"
with Joseph Bondy-Denomy, PhD, and Carol A. Gross, PhD
Catherine C. Smith, MD
"Defining structure, function and therapeutic impact of oncogenic FLT3 mutations"
with Neil P. Shah, MD, PhD
Adam J. Stevens, PhD
"Synthetic adhesion molecules: redirecting cell infiltration and organization"
with Wendell A. Lim, PhD
Kouki Touhara, PhD
"Investigating chemical signaling between gut enteroendocrine cells and intrinsic primary afferent neurons"
with David Julius, PhD
Linda T. Vo, PhD
"Off-the-shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen-sensing circuits"
with Jeff A. Bluestone, PhD
Yichen Xu, PhD
"Elucidating a non-classical role of ER in gene expression and breast cancer progression"
with Davide Ruggero, PhD
Ziyang Zhang, PhD
"Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch"
with Kevan M. Shokat, PhD
Yale University
Sigrid Nachtergaele, PhD
"Identifying novel mechanisms of gene expression regulation through mRNA modifications"
The Johns Hopkins University School of Medicine
Xintong Dong, PhD
"Investigating ligand-receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing"
with Xinzhong Dong, PhD
Boston Children's Hospital
Liudmila Andreeva, PhD
"Making an inflammasome: Structural and biochemical elucidation of NLRP3 inflammasome activation"
with Hao Wu, PhD
Megan Insco, MD, PhD
"Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets"
with Len Zon, MD
Aaron L. Moye, PhD
"Role of Lgr6-expressing Mesenchymal cells in lung cancer initiation and progression"
with Carla Kim, PhD
Esteban A. Orellana Vinueza, PhD
"Role of METTL1-WDR4 tRNA methyltransferase complex in cancer"
with Richard I. Gregory, PhD
Yuxiang Zhang, PhD
"Mechanisms that promote DNA double strand break clusters in brain and liver"
with Frederick W. Alt, PhD
Brigham and Women's Hospital
Kunitoshi Chiba, PhD
"The role of a tumor suppressor gene ASXL1 in immune evasion during tumorigenesis"
with Stephen Elledge, PhD
Gabriel K. Griffin, MD
"Enhancing cancer immunotherapy through epigenetic modulation of the repetitive genome"
with Bradley E. Bernstein, MD, PhD, and Arlene H. Sharpe, MD, PhD
Dana-Farber Cancer Institute
Edmond M. Chan, MD
"Validating a novel synthetic lethal target for microsatellite unstable cancers"
with Adam J. Bass, MD
Phillip A. Dumesic, MD, PhD
"Identification of muscle-secreted factors responsible for local and systemic effects of exercise"
with Bruce M. Spiegelman, PhD
Adam D. Durbin, MD, PhD
"Interrogation of neuroblastoma dependencies and non-coding RNAs on the core-regulatory circuitry for therapeutic inhibition"
with A. Thomas Look, MD
Eric S. Fischer, PhD
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
Christopher J. Gibson, MD
"The biology and clinical implications of clonal hematopoiesis in cancer patients"
with Benjamin L. Ebert, MD, PhD
Lillian M. Guenther, MD
"Investigation of CITED2 as a novel dependency in Ewing sarcoma"
with Kimberly Stegmaier, MD
Tikvah K. Hayes, PhD
"Systematic genomic and functional analysis of small cell lung cancer"
with Matthew L. Meyerson, MD, PhD
Whitney Johnson, PhD
"Using organoid cancer models to identify genome catastrophe mechanisms"
with David Pellman, MD
Joseph D. Mancias, MD, PhD
“Identifying the pancreatic tumor MHC-I ligandome in response to ionizing radiation for combination radiation-immunotherapy”
Jasper E. Neggers, PhD
"Validation of VPS4A as a synthetic lethal target in cancers with VPS4B loss on chromosome 18q"
with Andrew J. Aguirre, MD, PhD, and Todd R. Golub, MD
Sarah Naomi Olsen, PhD
"Targeted degradation of the MLL-AF9 fusion oncoprotein in acute myeloid leukemia"
with Scott A. Armstrong, MD, PhD
Matthew G. Oser, MD, PhD
"Targeting neuroendocrine differentiation as a novel therapeutic strategy for small cell lung cancer"
with William G. Kaelin, Jr., MD
Harshabad Singh, MBBS
"Cellular origins of Barrett’s esophagus and its role in development of adenocarcinoma"
with Ramesh A. Shivdasani, MD, PhD
Collin Tokheim, PhD
"Computationally identifying oncogenic substrates of the ubiquitin-proteasome system in human cancers"
with X. Shirley Liu, PhD, and Eric S. Fischer, PhD
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies"
with Geoffrey I. Shapiro, MD, PhD
Harvard Medical School
Amelia N. Chang, PhD
"The role of activity-regulated gene expression in human brain evolution"
with Michael E. Greenberg, PhD
Anne E. Dodson, PhD
"Transgenerational inheritance of structure-based infections"
with Scott G. Kennedy, PhD
Erin E. Duffy, PhD
"Activity-dependent changes in RNA stability as a mechanism for synaptic plasticity"
with Michael E. Greenberg, PhD
Nagarajan Nandagopal, PhD
"Signal integration by bHLH circuits to enable cell fate decisions"
with Galit Lahav, PhD, and Sean Megason, PhD
Natasha M. O'Brown, PhD
"Molecular and cellular mechanisms of transcytosis regulation in blood-brain barrier function"
with Sean G. Megason, PhD, and Chenghua Gu, PhD
Nikit Patel, PhD
"Determining the core genetic regulators of the erythro-myeloid switch"
with Allon Klein, PhD
Sarah J. Pfau, PhD
"Investigating the molecular determinants of blood-brain barrier heterogeneity"
with Chenghua Gu, PhD
Maxim Pimkin, MD, PhD
"Divergent core transcriptional circuitries highlight context-specific vulnerabilities in AML"
with Stuart Orkin, MD
Deepshika Ramanan, PhD
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
with Christophe Benoist, MD, PhD
Denis Schapiro, PhD
"Single cell pharmacodynamics and spatial signatures of drug response in the intact tumor microenvironment"
with Aviv Regev, PhD, and Peter K. Sorger, PhD
Jonathan G. Van Vranken
"Systematic identification of metabolite-protein interactions in human cells"
with Steven Gygi
Shou-Wen Wang, PhD
"Inferring cell fate choice from clonal and transcriptomic data, with application to hematopoiesis"
with Allon M. Klein, PhD
Harvard University
Grace E. Kenney, PhD
"Two enzymatic routes towards diazo biosynthesis in cytotoxic natural products"
with Emily P. Balskus, PhD
Thomas R. LaBar, PhD
"Elucidating the mechanisms of cellular evolution with experimental evolution"
with Andrew W. Murray, PhD
Monica E. McCallum, PhD
"Understanding alanosine biosynthesis to discover new cancer chemotherapeutics"
with Emily P. Balskus, PhD
Massachusetts General Hospital
Priscilla K. Brastianos, MD
"Investigation of novel targeted therapeutic approaches for brain metastases"
with Keith T. Flaherty, MD and Tracy T. Batchelor, MD
Jan P. Schuemann, PhD
“Using extreme dose rates to protect healthy tissue in proton radiation therapy”
Kurt J. Warnhoff, PhD
"Molybdenum cofactor biosynthetic enzymes modulate miRNA biology and development"
with Gary B. Ruvkun, PhD
Massachusetts Institute of Technology
Michael E. Birnbaum, PhD
"Decoding and reprogramming tumor-infiltrating T cells by pMHC-targeted lentiviruses"
Lindsay M. LaFave, PhD
"Investigating epigenetic mechanisms of transformation in SWI/SNF-mutant non-small cell lung cancer"
with Tyler Jacks, PhD
Jon McGinn, PhD
"Dissecting the genetic networks underlying host subversion during Rickettsia infection"
with Rebecca Lamason, PhD, and Michael Laub, PhD
Whitehead Institute for Biomedical Research
Laura Blanton, PhD
"The impact of sex chromosome constitution on immune cell gene expression and function"
with David C. Page, MD
Elizabeth A. Boydston, PhD
"Exploring the cell adhesion landscape through host-pathogen interactions"
with Sebastian Lourido, PhD
Daniel H. Lin, PhD
"Global influence of mRNA conformation on eukaryotic translational regulation"
with David P. Bartel, PhD
Princeton University
Caroline Bartman, PhD
"Systems analysis of in vivo tumor and stromal cell metabolism in pancreatic ductal adenocarcinoma"
with Joshua Rabinowitz, MD, PhD
Andrew A. Bridges, PhD
"Bacterial cell fates: The role of quorum sensing in biofilm patterning"
with Bonnie L. Bassler, PhD
Antony J. Burton, PhD
"Sculpting chromatin architecture in live cells using protein chemistry"
with Tom W. Muir, PhD
Columbia University
Jessie A. Brown, PhD
"Master regulators of drug resistance in relapsed acute lymphoblastic leukemia"
with Adolfo A. Ferrando, MD, PhD
J. Brooks Crickard, PhD
"Visualizing the strand invasion during homologous recombination on the single molecule level"
with Eric C. Greene, PhD
Memorial Sloan Kettering Cancer Center
Vinod P. Balachandran, MD
"Recombinant interleukin-33 immunotherapy for pancreatic cancer"
with Steven D. Leach, MD, and Jedd D. Wolchok, MD, PhD
Adrienne A. Boire, MD, PhD
"Molecular determinants of leptomeningeal metastasis: a translational approach"
with Joan Massagué, PhD
Andrew J. Dunbar, MD
"Interrogating functional contribution of JAK2V617F in the maintenance of myeloproliferative neoplasms"
with Ross L. Levine, MD
Siting Gan, PhD
"In situ single-cell dissection of the tumor-microenvironment interplay mediating brain metastasis"
with Joan Massagué, PhD, and Dana Pe'er, PhD
Karuna Ganesh, MD, PhD
"Leveraging patient-derived organoid models to define the molecular determinants of metastatic regeneration"
with Joan Massagué, PhD
Matthew D. Hellmann, MD
"Defining intratumoral and peripheral mechanisms mediating initiation of response, durability, and resistance to PD-1 blockade to inform rational immunotherapeutic development in NSCLC"
with Charles M. Rudin, MD, PhD, and Jedd D. Wolchok, MD, PhD
Andrew M. Intlekofer, MD, PhD
"Metabolic coupling of the hypoxic niche to stemness"
with Ross L. Levine, MD
Christopher A. Klebanoff, MD
"Clinical development of next-generation T cell receptor (TCR)-based adoptive immunotherapies for the treatment of patients with common epithelial malignancies"
with Michel Sadelain, MD, PhD, and Larry Norton, MD
Piro Lito, MD, PhD
"Modeling responses to targeted ERK signaling inhibition at the single-cell level"
with Neal X. Rosen, MD, PhD, and Charles M. Rudin, MD, PhD
Kaixian Liu, PhD
"The studies of double-strand break proteins in germline genome transmission"
with Scott Keeney, PhD, and Shixin Liu, PhD
Elli Papaemmanuil, PhD
"Biological and clinical implications of allelic imbalances in clonal hematopoiesis and subsequent risk of therapy related leukemia"
New York University School of Medicine
Robert S. Banh, PhD
"Metabolic contribution of sensory neurons to pancreatic tumorigenesis and serine metabolism, via peripheral axons"
with Alec C. Kimmelman, MD, PhD, and Michael Pacold, MD, PhD
Sophia Tintori, PhD
"Mechanisms of radiation tolerance in Caenorhabditis from Chernobyl"
with Matthew Rockman, PhD
Stony Brook University
Benjamin L. Martin, PhD
"Cell cycle regulation of cellular behaviors associated with cancer metastasis"
The Rockefeller University
Aleksey Chudnovskiy, PhD
"Defining dendritic cell-T cell interaction history within the tumor microenvironment using enzymatic labeling"
with Gabriel D. Victora, PhD
Gregory P. Donaldson, PhD
"Cross-talk between B lymphocytes and bacteria in the maintenance of a non-inflammatory mucosal microbiome"
with Daniel Mucida, PhD
Yusong R. Guo, PhD
"Structural and mechanistic characterization of mechanosensitive Piezo channels"
with Roderick MacKinnon, MD
Yadira M. Soto-Feliciano, PhD
"Dissecting the role of Menin in acute leukemia"
with C. David Allis, PhD
Linghe Xi, PhD
"WNT signaling and fate specification of normal versus tumorigenic stem cells"
with Elaine Fuchs, PhD
Weill Cornell Medicine
Christopher E. Barbieri, MD, PhD
"Subtype-specific modes of clinical and molecular progression in prostate cancer"
with Lewis C. Cantley, PhD
John R. Ferrarone, MD
"Seeking and evaluating novel therapeutic targets in human lung adenocarcinomas with loss-of-function mutations in LKB1"
with Harold E. Varmus, MD
Eric E. Gardner, PharmD, PhD
"Interrogating lung adenocarcinoma transformation to small cell lung cancer at single cell resolution"
with Harold E. Varmus, MD
Duke University
Lawrence A. David, PhD
"Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes"
Nicholas C. DeVito, MD
"Investigating the role of EMT-mediated dendritic cell tolerization in checkpoint inhibitor resistance"
with Brent A. Hanks, MD, PhD
Oregon Health & Science University
Jeremy Copperman, PhD
"Whole-cell modeling for the prediction and control of micro-environmentally regulated proliferative and migratory variability"
with Daniel M. Zuckerman, PhD, and Joe W. Gray, PhD
University of Pennsylvania, Philadelphia
Brian C. Capell, MD, PhD
"Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis"
with Shelley L. Berger, PhD
Geoffrey P. Dann, PhD
"Proteomics to bridge protein arginylation, chromatin, and cancer"
with Benjamin A. Garcia, PhD
University of Texas Southwestern Medical Center
Elise C. Jeffery, PhD
"Characterizing a new hematopoietic stem cell niche factor"
with Sean Morrison, PhD
Xiaochun Li, PhD
“Investigations on Patched, a tumor suppressor, and its regulation in Hedgehog pathway”
University of Utah
Matthew P. Miller, PhD
"Deciphering tension-dependent stabilization of kinetochore-microtubule interactions"
Fred Hutchinson Cancer Research Center
Tal Einav, PhD
"Quantifying a polyclonal immune repertoire's ability to bind influenza"
with Jesse D. Bloom, PhD, and Jonathan W. Yewdell, MD, PhD
Jay F. Sarthy, MD, PhD
"Characterization of the epigenomic landscape of diffuse midline gliomas"
with Steven Henikoff, PhD, and James Olson, MD, PhD
Washington University
Vivek K. Arora, MD, PhD
"Defining a targetable oncogenic dyad in bladder cancer"
with Lee Ratner, MD, PhD
