Cutting-edge Research by the Best and Brightest

Damon Runyon cancer researchers work in technologically advanced labs and leading hospitals across the country.

Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.

Scientists by State

City of Hope

L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia" with Stephen J. Forman, MD, FACP
Mingye Feng, PhD
"Macrophage-mediated immunosurveillance in metastasis"

Stanford University

Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients" with Linda Boxer, MD, PhD, and Michael Snyder, PhD
Christopher J. Cambier, PhD
"In vivo characterization of mycobacterial cording" with Carolyn Bertozzi, PhD
Jennifer L. Caswell-Jin, MD
"Breast cancer evolution and resistance in response to HER2-targeted therapy" with Christina N. Curtis, PhD, and Allison W. Kurian, MD, MSc
Scott J. Dixon, PhD
"Exploring the role of reductive stress in promoting cancer cell death"
Kelsie A. Eichel, PhD
Mechanisms of polarized membrane protein trafficking with Kang Shen, PhD
Ryan A. Flynn, MD, PhD
"The interplay between cellular metabolism and RNA homeostasis in disease" with Carolyn R. Bertozzi, PhD
Victoria Hung, PhD
"Defining the post-translational landscape of ribosomes in control of gene regulation and cell fate" with Maria Barna, PhD
John C. Janetzko, PhD
"A biophysical approach to studying GRK-GPCR complexes" with Brian K. Kobilka, MD
David M. Kurtz, MD, PhD
"Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non-Hodgkin lymphoma" with Arash A. Alizadeh, MD, PhD
Kathrin Leppek, PhD
"Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development" with Maria Barna, PhD
Chuan Li, PhD
Quantifying epistasis among tumor suppressor genes and revealing the underlying expression profiles at the single-cell level with Dmitri Petrov, PhD
Fangfei Qu, PhD
"Decoding the molecular and cellular mechanisms underlying the growth of brain metastases" with Julien Sage, PhD
Jianjin Shi, PhD
"Biochemical and genetic dissection of axon degeneration" with Marc Tessier-Lavigne, PhD
Shaogeng (Steven) Tang, PhD
"Toward small-molecule inhibitors against human immune checkpoint PD-1" with Peter S. Kim, PhD
Kathryn R. Taylor, PhD
"The effect of neuronal activity on pediatric glioma invasion" with Michelle L. Monje, MD, PhD
Albert G. Tsai, MD, PhD
"Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis" with Sean Bendall, PhD
Jing Lin Xie, PhD
"Remembering the past: epigenetic mechanisms of cancer drug resistance" with Daniel F. Jarosz, PhD
Leeat Yankielowicz-Keren, PhD
"Studying the tumor immune microenvironment in breast cancer using a novel multiplexed imaging platform" with Michael R. Angelo, MD, PhD

Stanford University School of Medicine

Christopher P. Lapointe, PhD
"Regulatory roles of the 3' untranslated region in human translation" with Joseph Puglisi, PhD

The Salk Institute for Biological Studies

Corina E. Antal, PhD
"Stromal reprogramming as a therapeutic approach in pancreatic cancer" with Ronald M. Evans, PhD
Jeanine L. Van Nostrand, PhD
"Elucidating the AMPK-dependent regulation of mTOR signaling in the metabolic checkpoint of tumorigenesis" with Reuben J. Shaw, PhD

The Scripps Research Institute

Marsha M. Hirschi, PhD
Molecular engineering of an optically controlled glutamate receptor with Gabriel C. Lander, PhD
Xiaoyu Zhang, PhD
Discovery of chemical probes that support targeted protein degradation in human cancer with Benjamin F. Cravatt, PhD

University of California, Berkeley

Gina V. Caldas, PhD
"Analysis of CSR- function in C. elegans embryonic cell division" with Abby F. Dernburg, PhD
Allison Didychuk, PhD
Viral mimics of host transcription factors in oncogenic herpesviruses with Britt Glaunsinger, PhD
Stephanie Gates, PhD
Decoding the ubiquitin receptor recognition mechanism of the 26S proteasome with Andreas Martin, PhD
Nicholas T. Ingolia, PhD
"Cis-regulatory code for the translational control of gene expression"
Jamie Lahvic, PhD
Uncovering cell non-autonomous mechanisms of tumor suppression with Iswar Hariharan, MMBS, PhD
Andrew C. Murley, PhD
"Cell non-autonomous communication of ER stress resistance" with Andrew G. Dillin, PhD
Roberto Zoncu, PhD
"Identifying and disabling organelle circuits that fuel cancer cell metabolism"

University of California, Los Angeles

Magdalena E. Potok, PhD
"The relationship between epigenetic gene silencing, nuclear architecture, and genome stability" with Steven E. Jacobsen, PhD
Christina M. Termini, PhD
"Proteoglycan remodeling of the bone marrow niche regulates hematopoietic stem cell regeneration" with John P. Chute, MD

University of California, San Diego

Richard W. Baker, PhD
"Understanding the mechanism of SWI/SNF-mediated chromatin remodeling and its misregulation in cancer" with Andres E. Leschziner, PhD

University of California, San Francisco

Özlem Aksoy, PhD
"Understanding the role of translational control in humanized mouse models for medulloblastoma" with Davide Ruggero, PhD
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to osimertinib in EGFR-mutant lung cancer" with Trever G. Bivona, MD, PhD
Vladislav Belyy, PhD
"Mapping the unfolded protein response signaling network with optogenetic actuators" with Peter Walter, PhD
Julia C. Carnevale, MD
"Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects" with Alan Ashworth, PhD
Kyle G. Daniels, PhD
"Controlling T cell signaling and fate choice using synthetic receptors" with Wendell Lim, PhD
Qi Hu, PhD
"Design of inhibitors of cancer-associated mutant GNAS" with Kevan M. Shokat, PhD
Jeffrey A. Hussmann, PhD
"Genome-wide measurement of ribosome spacing on individual transcripts" with Carol Gross, PhD
Brian J. Laidlaw, PhD
"Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer" with Jason Cyster, PhD
Kara L. McKinley, PhD
"Mechanisms and functions of cellular rearrangements in epithelia" with Ronald D. Vale, PhD
Lyndsay M. Murrow, PhD
"Fate specification of mammary stem cells by cell self-sorting" with Zev J. Gartner, PhD
Trang Nguyen, PhD
Bypassing the unresponsiveness of T cell anergy and exhaustion with Arthur Weiss, MD, PhD
Thomas M. Norman, PhD
"Identifying the stochastic determinants of drug resistance" with Jonathan S. Weissman, PhD
Rushika M. Perera, PhD
"Mechanisms of cellular transformation at the single organelle level"
Catherine C. Smith, MD
"Defining structure, function and therapeutic impact of oncogenic FLT3 mutations" with Neil P. Shah, MD, PhD
Peter J. Turnbaugh, PhD
"The gut microbiome: an unexpected contributor to cancer drug resistance"
Linda T. Vo, PhD
"Off-the-shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen-sensing circuits" with Jeff A. Bluestone, PhD
Lan Wang, PhD
"Conferring organelle-specificity to tail-anchored proteins" with Peter Walter, PhD
Yichen Xu, PhD
"Elucidating a non-classical role of ER in gene expression and breast cancer progression" with Davide Ruggero, PhD
Dian Yang, PhD
Dissecting intratumoral heterogeneity and hierarchy at single cell resolution with Jonathan S. Weissman, PhD, and Trever G. Bivona, MD, PhD
Ziyang Zhang, PhD
"Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch" with Kevan M. Shokat, PhD
Xin Zhou, PhD
"Engineering 'Glue' domains to enable cryo-EM study of small cancer protein structures" with James A. Wells, PhD

Yale University

Esen Sefik, PhD
"The effect of microbes, diet on the intestinal immune system in the context of obesity and cancer" with Richard A. Flavell, PhD
Seyed Fakhreddin Torabi, PhD
"Evolution of triplex-forming RNAs from random sequences: a search for additional MALAT1-like triplex motifs" with Joan Steitz, PhD

Northwestern University

Jaehyuk Choi, MD, PhD
"Identification of genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma" with Stephen D. Miller, PhD, and John D. Crispino, PhD

The University of Chicago

Michael W. Drazer, MD
"Defining leukomogenic mechanisms in hereditary hematologic malignancies" with Lucy A. Godley, MD, PhD
Sigrid Nachtergaele, PhD
"The dynamic N1-methyladenosine methylome in eukaryotic mRNA" with Chuan He, PhD

University of Illinois, Urbana-Champaign

Daniel J. Blair, PhD
"An automated small molecule synthesizer for the discovery of new anti-cancer agents" with Martin D. Burke, MD, PhD

Johns Hopkins University

Vu Quang Nguyen, PhD
"Role of chromatin organization in dynamics of transcription initiation" with Carl Wu, PhD

National Institutes of Health

Danfeng Cai, PhD
"Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states" with Jennifer Lippincott-Schwartz, PhD
Warakorn Kulalert, PhD
"Characterization of the microbiota-mediated cutaneous neuroimmune interface and its impacts on tumorgenesis and cancer therapy" with Yasmine Belkaid, PhD

The Johns Hopkins University

Stacy L. Cooper, MD
"The Cebpa +37kb enhancer is a critical target of transformation in acute myeloid leukemia" with Alan D. Friedman, MD
Daniel H. Goldman, PhD
"Elucidating the role of the exon junction complex in regulating translation of spliced mRNA" with Rachel Green, PhD
Michael A. Koldobskiy, MD, PhD
"DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia" with Andrew P. Feinberg, MD
Cara A. Rabik, MD, PhD
"Determination of the role of WT1 in hematopoiesis and leukemogenesis" with Patrick A. Brown, MD

The Johns Hopkins University School of Medicine

Xintong Dong, PhD
"Investigating ligand-receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing" with Xinzhong Dong, PhD
Evan J. Worden, PhD
"The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation" with Cynthia Wolberger, PhD
Boris Zinshteyn, PhD
"Mechanisms of splicing-independent nonsense-mediated mRNA decay" with Rachel Green, PhD

University of Maryland

Christopher M. Jewell, PhD
"Harnessing intra-lymph node controlled release to study and enhance tumor immunity"

Boston Children's Hospital

Megan Insco, MD, PhD
"Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets" with Len Zon, MD
Yuxiang Zhang, PhD
Mechanisms that promote DNA double strand break clusters in brain and liver with Frederick W. Alt, PhD

Brigham and Women's Hospital

Ann Mullally, MD
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms" with Benjamin L. Ebert, MD, PhD, and Jerome Ritz, MD
Emma Watson, PhD
"Metabolic stress response: Exploring transcript-level regulation of metabolic feedback" with Stephen Elledge, PhD

Dana-Farber Cancer Institute

Pavan Bachireddy, MD
"Coevolution of tumor and T cell heterogeneity following immunotherapy" with Catherine J. Wu, MD
Giada Bianchi, MD
"Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis" with Kenneth C. Anderson, MD
Phillip A. Dumesic, MD, PhD
"Identification of muscle-secreted factors responsible for local and systemic effects of exercise" with Bruce M. Spiegelman, PhD
Adam D. Durbin, MD, PhD
Interrogation of neuroblastoma dependencies and non-coding RNAs on the core-regulatory circuitry for therapeutic inhibition with A. Thomas Look, MD
Eric S. Fischer, PhD
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
Christopher J. Gibson, MD
"Elucidating the connection between clonal hematopoiesis and lymphoma in humans" with Benjamin L. Ebert, MD, PhD
Lillian M. Guenther, MD
"Investigation of CITED2 as a novel dependency in Ewing sarcoma" with Kimberly Stegmaier, MD
Tikvah K. Hayes, PhD
"Systematic genomic and functional analysis of small cell lung cancer" with Matthew L. Meyerson, MD, PhD
Amanda Balboni Iniguez, PhD
"Targeting the EWS-FLI oncoprotein in Ewing sarcoma with CDK12/13 inhibitors" with Kimberly Stegmaier, MD
Whitney Johnson, PhD
Using organoid cancer models to identify genome catastrophe mechanisms with David Pellman, MD
Loretta S. Li, MD
"Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia" with David M. Weinstock, MD
Sarah Naomi Olsen, PhD
Targeted degradation of the MLL-AF9 fusion oncoprotein in acute myeloid leukemia with Scott A. Armstrong, MD, PhD
Geoffrey R. Oxnard, MD
"Noninvasive genotyping of cell-free plasma DNA (cfDNA) as a tool for guiding personalized lung cancer care" with Pasi A. Janne, MD, PhD
Harshabad Singh, MBBS
"Cellular origins of Barrett’s esophagus and its role in development of adenocarcinoma" with Ramesh A. Shivdasani, MD, PhD
Neil T. Umbreit, PhD
"Elucidating the mechanism of chromosome bridge resolution" with David S. Pellman, MD
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies" with Geoffrey I. Shapiro, MD, PhD
Eric Wang, PhD
"Enhancing anti-tumor immunity via pharmacological inhibition of kinases" with Nathanael Gray, PhD

Harvard Medical School

Justin A. Bosch, PhD
"Characterizing novel molecules and mechanisms that mediate cell-cell communication" with Norbert Perrimon, PhD
Anne E. Dodson, PhD
"Transgenerational inheritance of structure-based infections" with Scott G. Kennedy, PhD
Ivana Gasic, Dr.Sc.
"Molecular elucidation of the interphase microtubule integrity response (MIR)" with Timothy Mitchison, PhD
Zhejian Ji, PhD
"Function of the Cdc48 ATPase in protein degradation" with Tom A. Rapoport, PhD
Lucy Liu, PhD
"In vivo characterization of muscle autophagy in health and disease" with Norbert Perrimon, PhD
Nagarajan Nandagopal, PhD
Signal integration by bHLH circuits to enable cell fate decisions with Galit Lahav, PhD, and Sean Megason, PhD
Natasha M. O'Brown,